|View this answer. Water ( H2O H 2 O) can act as a nucleophile and electrophile. There are lone pairs of electrons on the oxygen atom which allow it to donate... See full answer below.
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Is h2o a strong nucleophile

H2O is highly polar and electron dense /electron rich, making it a nucleophile. It also has lone pairs and the electrons are much more associated with the central atom oxygen because of its electronegativity. The central atom therefore is electron rich and readily available to donate electrons. CO2, a nonpolar molecule, has the central atom ...

So for instance H2O is not a great nucleophile, but H2S is a rather good one. So to recap: strong bases (equal to or stronger than NH3) are nucleophiles, and so are weak bases if they are polarizable. If you don't remember how to tell how strong a base is, or don't remember what polarizability is, you should look those up separately.Which is the strongest nucleophile? a) OH. b) CH3CH2O. c) CH3COO. d) CH3CH2OH. e) H20. I know the answer is b . Please explain how it is BIn contrast to the cases with carbon or hydrogen nucleophiles, oxygen and nitrogen nucleophiles can be good leaving groups. Typically, the reaction is catalyzed either by acid or base as discussed below. For example: in aqueous solution, most aldehydes and ketones will react with water to produce a hydrate.My understanding: Strong nucleophiles are able to provide/donate electrons. What's wrong with my logic/understanding? 1.)H2S is neutral so it doesn't seem like it would have any extra electrons to donate. 2.) S is fairly electronegative, so it will hold onto its electrons making it less likely to donate any of its electrons. Thanks in advance!!

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In both nucleophilic substitution reactions, the rate-determining step does not include nucleophiles so its health or strength does not produce or put any effect on the Sn1 reaction mechanism. But some of the neutral substances like H2O, ROH, RCOOH usually act as nucleophiles as well as solvents.,A nucleophile is attracted to a positive region and since the hydroxide ion is negative it will be more attracted than the neutral water molecule. Water doe...Which of the following statements is not correct for a nucleophile? Hard. NEET. View solution > Assertion Methylene has a sextet of e s. Reason Methylene behaves as a nucleophile. Medium. View solution > The decreasing leaving group order of the following is: i. F ...Certain Nucleophile orders are. (ii) In weakly polar aprotic solvents, CsF > RbF > KF > NaF > LiF. (iii) Bases are better nucleophiles than their conjugate acids. For example, OH- > H2O and > NH3. (v) When nucleophilic and basic sites are same, nucleophilicity parallels basicity. For example, RO- > HO- > R - CO - O-.

Which is better nucleophile OH or C2H5O? OH – The Nucleophile/Base — Master … It’s both a strong base and a good nucleophile. Similarly, when it’s forming a bond to carbon (as in a substitution reaction) we say it’s acting as a nucleophile. Why is ethanol a bad nucleophile? In the SN1 pathway, ethanol acts as a nucleophile. ,In Williamson's synthesis, if a tertiary alkyl halide is used, an alkene is the only reaction product and no ether is formed.(CH3)3CBr + NaOCH3 → (CH3)2C=CH2 + NaBrIt is because alkoxides are not only nucleophiles but also strong bases as well. They react with alkyl halides leading to elimination reaction.the consumption of the electrophiles [16–19]. By combining strong electrophiles with weak nucleo-philes and weak electrophiles with strong nucleophiles, we arrived at second-order rate constants be-tween 10–5and 5 × 107M–1s–1at 20 °C (Figs. 3 and 4) [20]. As pointed out previously, free and paired In S N 2 reactions, the nucleophile actively displaces the leaving group in a backside attack. For this to occur, the nucleophile must be strong, and the substrate cannot be sterically hindered. Therefore, the less substituted the carbon, the more reactive it is in S N 2 reactions. Note that this is the opposite of the trend for S N 1 reactions ...On the other hand, the relative basicity and thus strong hydrogen-bond forming capabilities of $\ce{F^-}$ makes it a poorer nucleophile in water. Rates of reaction between fluoride anion and some electrophilic atom are slowed because the fluoride anion is trapped (strongly solvated) by water molecules.May 01, 2007 · In summary, very strong evidence is presented that the active nucleophile in VpAP catalysis is not delivered by the metal centre. The most likely candidate for the nucleophile is a water molecule hydrogen-bonded to a carboxylate oxygen atom, itself a ligand to a Zn(II) ion, of an active-site glutamate residue, Glu 152. These findings prompt a ... The reaction between primary halogenoalkanes and water - the S N 2 mechanism. Water as a nucleophile. A nucleophile is a species (an ion or a molecule) which is strongly attracted to a region of positive charge in something else. Nucleophiles are either fully negative ions, or else have a strongly - charge somewhere on a molecule.Third-order rate constants (kNu)H (M-2 s-1) for the hydronium ion catalyzed reactions of a range of nucleophiles with N-chlorotaurine (1) in water at 25 °C and I = 0.5 (NaClO4) are reported. The solvent deuterium isotope effects on hydronium ion catalysis of the reaction with 1 of bromide and iodide ion are (kBr)H/(kBr)D = 0.30 and (kI)H/(kI)D = 0.54, respectively. The inverse nature of these ... What Makes a Good Nucleophile? 1. Wants to give away electrons (good Lewis base). HO- better than H2O (bases always better than their conjugate acids) better than (less electronegative atom means more willing to give up e-) HS-better than Cl-NH3 H2O + + What Makes a Good Nucleophile? 2. More polarizable. (Bigger.) So, I-is a better nucleophile ...HO- is a better nucleophile than H2O. NH2(-) is a better nucleophile than NH3. HS(-) is a better nucleophile than H2S. Electronegativity. Nucleophilicity increases as you go to the left along the periodic table. What is difference between Nucleophile and Electrophile? Electrophiles are electron acceptors while nucleophiles are electron donors.We're being asked to determine the strongest nucleophile among H 2 O, H 2 S, or H 2 Se in a protic solvent. Recall that the rules for nucleophile strength are: 1. A negative charge will always be a stronger nucleophile than its neutral counterpart. 2. The bulkier the base, the more basic and less nucleophilic it is. 3.Which is the strongest nucleophile group of answer choices? In an aprotic solvent, H2O is the strongest nucleophile. In a protic solvent, however, H2Se is the strongest nucleophile. This means in a protic solvent, the strongest nucleophile among the given is C. H2Se.The weak conjugate bases are poor nucleophiles. Nucleophilicity increases in parallel with the base strength. Thus, amines, alcohols and alkoxides are very good nucleophiles. Base strength is a rough measure of how reactive the nonbonding electron pair is; thus, it is not necessary for a nucleophile to be anionic.

H20 is a nucleophile it has a free lone pair of electrons which is a main feature of nucleophile, however, it is a weak nucleophile,Idle arena gift code redditA nucleophile is an electron-rich molecule that can form covalent bonds by donating electrons to electron-poor sites. Many molecules can act as a nucleophile in a chemical reaction, though some are stronger than others. Learn more about what constitutes a strong or weak nucleophile below!attack occurs when the nucleophile approaches the more substituted carbon. * it is now generally accepted that the initial protonation or Lewis acid coordination is a fast, reversible step, the rate limiting step being the reaction of the complex with the nucleophile. ** The terminology used is a legacy from work on the neutral or A nucleophile is attracted to a positive region and since the hydroxide ion is negative it will be more attracted than the neutral water molecule. Water doe...

Answer (1 of 3): Not at all. It should be based on 1) size or sterics 2) polarizability 3) solvent effects water solubility —unless the solvent is http://water ...,How to apply for sales tax exemption in virginiaSN2 Reactions Definition: A nucleophile donates an electron pair to an electrophile to displace a leaving group. These are from the same molecule. 1 step Solvent :-Polar aprotic-Protic Reactant:-Strong nucleophile-Charged nucleophile Alkyl Halide:-Primary alkyl halide-Secondary alkyl halide Configuration: 1. inversion of configuration a. Is water a weak nucleophile? Yes, water is a nucleophile. Water is both a nucleophile and an electrophile. Can H+ be a nucleophile? Like carbon, hydrogen can be used as a nucleophile if it is bonded to a metal in such a way that the electron density balance favors the hydrogen side.

Weak, small nucleophiles that favor Sn1 reactions are shown below. Notice that several are the conjugate acids of strong nucleophiles. They are also typically neutral, but some have a delocalized negative charge. Large nucleophiles, especially if they are strong, have a tendency to act as Bronsted bases rather than as nucleophiles.,Certain Nucleophile orders are. (ii) In weakly polar aprotic solvents, CsF > RbF > KF > NaF > LiF. (iii) Bases are better nucleophiles than their conjugate acids. For example, OH- > H2O and > NH3. (v) When nucleophilic and basic sites are same, nucleophilicity parallels basicity. For example, RO- > HO- > R - CO - O-.Here in the entire mechanism , a strong Nucleophi le (Nu:-) , substitutes a good leaving group (X), as a weak Nucleophile (X:-) Since , a strong nucleophile (Nu:-) ,substitutes a weak nucleophile (X:-) , with the involvement of 2 species i.e CabdX(alkyl halide) & Nu:-(Nucleophile), the reaction mechanism is said to be a SN2 Mechanism ...carbocation intermediate, neutral nucleophile/base) Examples: H2O, ROH, H2S, RSH Strong, Non-Nucleophilic Bases (SNNB) - • Usually anions that are very sterically hindered, preventing them from attacking as nucleophiles (thus the phrase "non-nucleophilic") • Participate in E2 ONLY Examples:Weak, small nucleophiles that favor Sn1 reactions are shown below. Notice that several are the conjugate acids of strong nucleophiles. They are also typically neutral, but some have a delocalized negative charge. Large nucleophiles, especially if they are strong, have a tendency to act as Bronsted bases rather than as nucleophiles.Which would be the stronger nucleophile in a polar aprotic solvent? a) H2O or H2S b) (CH3)3P or (CH3)3N Homework Equations The Attempt at a Solution I'm really confused because in my book, it says that in protic solvents, the larger atoms (I-) are stronger nucleophiles than smaller ones (F-).Hint: A nucleophile is an element or molecule that seeks a positive centre in a chemical reaction, just as the nucleus in an atom since the nucleophile has an electron pair that is accessible for bonding. A base is a compound that reacts with hydrogen ions to neutralise an acid. The majority of bases are minerals that combine with acids to produce water and salts.nucleophile, the nature of the leaving group, the stability of any carbocation generated, temperature, the relative concentrations of reagents, etc. In general, the most stable nucleophiles are the best leaving groups, and can be readily identified - they are the conjugate bases of strong acids.if oxides have a lot of ring or angle strain and this makes them very reactive towards ring opening so in this video we'll look at the ring opening reactions of Epoque sides using strong nucleophiles so in the first step we add a strong nucleophile to our epoxide and in the second step we add a proton source and the nucleophile is going to end up opening opening the ring and adding an anti ... HO- is a better nucleophile than H2O. NH2(-) is a better nucleophile than NH3. HS(-) is a better nucleophile than H2S. Electronegativity. Nucleophilicity increases as you go to the left along the periodic table. Is KOEt a strong Nucleophile? Weak nucleophiles are neutral and don't bear a charge. Some examples are CH3OH, H2O, and CH3SH ...Good nucleophiles. Br–, HO–, RO–, CN–, N3–. Fair nucleophiles. NH3, Cl–, F–, RCO2–. Weak nucleophiles. H2O, ROH. VERY weak nucleophiles. RCO2H. As shown above, as a general rule, the anion of a reactant will be a better nucleophile than the neutral form. (i.e. RCO 2– is a better nucleophile than RCO 2 H) Hint: A nucleophile is an element or molecule that seeks a positive centre in a chemical reaction, just as the nucleus in an atom since the nucleophile has an electron pair that is accessible for bonding. A base is a compound that reacts with hydrogen ions to neutralise an acid. The majority of bases are minerals that combine with acids to produce water and salts.

SN2 Reactions Definition: A nucleophile donates an electron pair to an electrophile to displace a leaving group. These are from the same molecule. 1 step Solvent :-Polar aprotic-Protic Reactant:-Strong nucleophile-Charged nucleophile Alkyl Halide:-Primary alkyl halide-Secondary alkyl halide Configuration: 1. inversion of configuration a. Nucleophile and the leaving group are on different sides ...,Good nucleophiles. Br–, HO–, RO–, CN–, N3–. Fair nucleophiles. NH3, Cl–, F–, RCO2–. Weak nucleophiles. H2O, ROH. VERY weak nucleophiles. RCO2H. As shown above, as a general rule, the anion of a reactant will be a better nucleophile than the neutral form. (i.e. RCO 2– is a better nucleophile than RCO 2 H) The strong nucleophiles (Nu: -) that we have learned in this course are either hydride anion (H-) or alkyl anion (R-). As well, remember that attack by strong nucleophiles is not reversible. Hydride anion comes from hydride donor such as LiAlH 4 or NaBH 4 (however, NaBH 4 is not strong enough reaction on carboxylic acid derivatives except for ...However, primary alkyl halides do not undergo nucleophilic substitution reactions with weak nucleophiles in polar solvents, but only undergo nucleophilic substitution reactions with strong nucleophiles in non-polar solvents via the S N 2 mechanism. Water is a weak nucleophile and the primary carbocation is unstable. 14.Two lists of nucleophiles: H2O CH3CH2OH H3CO- CH3COO- OH- OH- H2N- CH3CH2O- H3COH (CH3)3CO- The first part is to give the strongest nucleophile in group 1. I picked H2N-because its the strongest base. Part two asks for the BEST . You can view more similar questions or ask a new question. Ask a New Question ...Good nucleophiles. Br–, HO–, RO–, CN–, N3–. Fair nucleophiles. NH3, Cl–, F–, RCO2–. Weak nucleophiles. H2O, ROH. VERY weak nucleophiles. RCO2H. As shown above, as a general rule, the anion of a reactant will be a better nucleophile than the neutral form. (i.e. RCO 2– is a better nucleophile than RCO 2 H) Example 2 uses KOEt (strong nucleophile). So we can rule out the SN1 and E1 here as well. Example 3 uses H2SO4. So we can rule out the E2, in addition to the SN2 we ruled out earlier because it's tertiary. Example 4 uses CH3OH. So we can rule out the SN2 and E2. Already, for each of these 4 examples, we've got it down from 4 possibilities to 2.Hint: A nucleophile is an element or molecule that seeks a positive centre in a chemical reaction, just as the nucleus in an atom since the nucleophile has an electron pair that is accessible for bonding. A base is a compound that reacts with hydrogen ions to neutralise an acid. The majority of bases are minerals that combine with acids to produce water and salts.R O − is strong nucleophile than O H − due to the presence of the inductive effect of R group electron density increases. In R C O O − the electrons are in conjugation, therefore, are not freely available to attack as a nucleophile.Charge. "The conjugate base is always a better nucleophile". HO- is a better nucleophile than H2O. NH2(-) is a better nucleophile than NH3. HS(-) is a better nucleophile than H2S. Electronegativity. Nucleophilicity increases as you go to the left along the periodic table.The reaction between primary halogenoalkanes and water - the S N 2 mechanism. Water as a nucleophile. A nucleophile is a species (an ion or a molecule) which is strongly attracted to a region of positive charge in something else. Nucleophiles are either fully negative ions, or else have a strongly - charge somewhere on a molecule.Use of a Strong Nucleophile to Generate a Strong Base Ian C. Stewart, Robert G. Bergman,* and F. Dean Toste* Center for New Directions in Organic Synthesis, Department of Chemistry, UniVersity of California, Berkeley, California 94720 Received March 19, 2003; E-mail: [email protected]; [email protected]

the stronger base is usually the stronger nucleophile. Thus, 2,2,2-trifluroethoxide (pK. a. 12) is a weaker base and nucleophile than ethoxide (pK. a. 16). A notable exception to this rule occurs when a vicinal (adjacent) atom carries a non-bonding electron pair. Two common examples of this exception, calledthe alpha effect, are hydroxide ion ... ,Nucleophile: If the reacting atom is the same in a series, nucleophilicity* parallels basicity (i.e. -OH > -OCH3 > -OCH2CH3 > H2O) For the halogens in GAS PHASE: F- > Cl- > Br- > I- For the halogens in SOLUTION: I- > Br- > Cl- > F- (due to solvation of nucleophile, rendering it inactive) Negatively charged nucleophiles give neutral productsthe stronger base is usually the stronger nucleophile. Thus, 2,2,2-trifluroethoxide (pK. a. 12) is a weaker base and nucleophile than ethoxide (pK. a. 16). A notable exception to this rule occurs when a vicinal (adjacent) atom carries a non-bonding electron pair. Two common examples of this exception, calledthe alpha effect, are hydroxide ion ... Is water a weak nucleophile? Yes, water is a nucleophile. Water is both a nucleophile and an electrophile. Can H+ be a nucleophile? Like carbon, hydrogen can be used as a nucleophile if it is bonded to a metal in such a way that the electron density balance favors the hydrogen side. Indeed, NH3 can act as an electrophile as well as a nucleophile. You should already know how NH3 acts as a nucleophile. It acts as an electrophile when a strong base abstracts a proton from it, forming an amide, as follows: [ the Base acts as a nucleophile, attacking the hydrogen of the NH3.is a good nucleophile (e.g. HCl, HBr, HI) or non-nucleophilic when the counterion is not a good nucleophile (e.g. H 2SO 4, H 3PO 4, HClO 4). While all of these are fairly strong acids the presence or absence of the nucleophile significantly affects their reactivity and kinds of product formed (e.g. HBr tends to do substitution typeThe nature of nucleophiles and leaving groups has strong influence on the rate of S N 2 reactions. Generally a good nucleophile or strong base is a poor leaving group, but hydrogen-bonding solvents can alter nucleophile reactivity Your water bill or local water utility customer service is a good starting point for information.attack occurs when the nucleophile approaches the more substituted carbon. * it is now generally accepted that the initial protonation or Lewis acid coordination is a fast, reversible step, the rate limiting step being the reaction of the complex with the nucleophile. ** The terminology used is a legacy from work on the neutral or Which is the strongest nucleophile? a) OH. b) CH3CH2O. c) CH3COO. d) CH3CH2OH. e) H20. I know the answer is b . Please explain how it is BNucleophile, Nu -, and displace (substitute) a nucleofugal Lewis base leaving group, Nfg -. Brønsted base, B -, and abstract an available proton. Spectator counter ion and do nothing at all. These reaction pathways are highly pertinent in organic chemistry.The nucleophile in this case is a phthalimide ("FTAL-im-id" or "FTAL-im-eyed") ion. The phthalimide ion is easily formed by a strong base such as potassium hydroxide, becaus the anion obtained is pretty stable.Two important categories to have straight are strong base/strong nucleophiles compared to strong nucleophiles only. For example, RO- like HO- (hydroxide) CH3O-, CH3CH2O-, ect. are both strong bases and strong nucleophiles. On the other hand, CN-, H2S (or any sulfur that is neutral or with a negative one formal charge), N3-, halides, among ...

Water ( H2O H 2 O) can act as a nucleophile and electrophile. There are lone pairs of electrons on the oxygen atom which allow it to donate... See full answer below. ,So, strong bases — substances with negatively charged O, N, and C atoms — are strong nucleophiles. Is water a nucleophile? Water: The oxygen atom of water has two lone pairs and a d- charge (oxygen is more electronegative than hydrogen). This suggests that water can behave an a nucleophile. Each hydrogen atom bears a d+ charge, so the ...Here in the entire mechanism , a strong Nucleophi le (Nu:-) , substitutes a good leaving group (X), as a weak Nucleophile (X:-) Since , a strong nucleophile (Nu:-) ,substitutes a weak nucleophile (X:-) , with the involvement of 2 species i.e CabdX(alkyl halide) & Nu:-(Nucleophile), the reaction mechanism is said to be a SN2 Mechanism ...In both nucleophilic substitution reactions, the rate-determining step does not include nucleophiles so its health or strength does not produce or put any effect on the Sn1 reaction mechanism. But some of the neutral substances like H2O, ROH, RCOOH usually act as nucleophiles as well as solvents.Nucleophile, Nu -, and displace (substitute) a nucleofugal Lewis base leaving group, Nfg -. Brønsted base, B -, and abstract an available proton. Spectator counter ion and do nothing at all. These reaction pathways are highly pertinent in organic chemistry.Weak Nucleophiles – • Typically neutral molecules • Participate in SN1-type substitutions Examples: H2O, ROH, H2S, RSH Strong Bases – • Usually anions with a full negative charge (easily recognizable by the presence of sodium, lithium or potassium counterions) • Participate in E2-type eliminations A Nucleophile which can execute nucleophilic attacks from two or more different places in the molecule (or ion) is called an Ambident Nucleophile. Attacks from these types of nucleophiles can often result in the formation of more than one product. An example of an ambident nucleophile is the thiocyanate ion which has the chemical formula of SCNIf the reaction is an alkene reacting with $\ce{Br2}$ in $\ce{H2O}$, the double bond will behave as a nucleophile attacking one of the Br's. Once the Br is attacked it will also keep the carbocation stable until it is attacked by the $\ce{H2O}$ molecule rather than the $\ce{Br-}$.Nucleophile, Nu -, and displace (substitute) a nucleofugal Lewis base leaving group, Nfg -. Brønsted base, B -, and abstract an available proton. Spectator counter ion and do nothing at all. These reaction pathways are highly pertinent in organic chemistry.

May 31, 2021 · The majority of nucleophiles seem to be Lewis bases, while vice versa. Many strong bases also are excellent nucleophiles, while others are poor bases. A substance might be a poor nucleophile as well as a strong base. A nucleophile is an exciton or electron-donating species that contributes two electrons to C-atom and forms a link with it. ,The nature of nucleophiles and leaving groups has strong influence on the rate of S N 2 reactions. Generally a good nucleophile or strong base is a poor leaving group, but hydrogen-bonding solvents can alter nucleophile reactivity Your water bill or local water utility customer service is a good starting point for information.where k is the rate constant for reactions with the nucleophile, k o is the rate constant for reaction when water is the nucleophile, s = 1.00 (for methyl bromide as substrate), and n is the relative nucleophilicity. The larger the n value, the greater the nucleophilicity. Thus, Table 1.6 shows that the thiosulfate ion (S 2 O 3 2 −, n = 6.4) is more nucleophilic than iodide (I -, n . = 5.0).HO- is a better nucleophile than H2O. NH2(-) is a better nucleophile than NH3. ... The greater the negative charge, the more likely an atom will give up its pair of electrons to form a bond. So,ph3 is a nucleophile. Jai hindWith the full negative charge localized on the single oxygen atom, it is a strong base, but the steric bulk from the methyl groups makes t-butoxide a rather poor nucleophile. Other non-nucleophilic bases include NaH, LDA, and DBU. The conjugate bases of the mineral acids make good nucleophiles, but terrible bases.

On the other hand, the relative basicity and thus strong hydrogen-bond forming capabilities of $\ce{F^-}$ makes it a poorer nucleophile in water. Rates of reaction between fluoride anion and some electrophilic atom are slowed because the fluoride anion is trapped (strongly solvated) by water molecules.,HO- is a better nucleophile than H2O. NH2(-) is a better nucleophile than NH3. ... The greater the negative charge, the more likely an atom will give up its pair of electrons to form a bond. So,ph3 is a nucleophile. Jai hindRecall that a Nucleophile is an electron pair donor (Lewis Base), and a Base is a proton acceptor (Bronsted-Lowry Base).. While the terms nucleophile and base often mean the same thing, there are some exceptions where basicity and nucleophilicity do not mirror each other. Relative Strength Rules: A negative charge will always be a stronger nucleophile than its neutral counterpart.Which is better nucleophile OH or C2H5O? OH – The Nucleophile/Base — Master … It’s both a strong base and a good nucleophile. Similarly, when it’s forming a bond to carbon (as in a substitution reaction) we say it’s acting as a nucleophile. Why is ethanol a bad nucleophile? In the SN1 pathway, ethanol acts as a nucleophile. 2. Weak acids are strong examples of a strong nucleophile. 3. A strong Arrhenius base is a strong nucleophile. 4. Nucleophiles tend to give electrons for the formation of a bond. 5. None of these. Solution: None of these. Explanation: Nucleophiles are rich in electron species that can form bonding electrophiles (electron-deficient species).Certain Nucleophile orders are. (ii) In weakly polar aprotic solvents, CsF > RbF > KF > NaF > LiF. (iii) Bases are better nucleophiles than their conjugate acids. For example, OH- > H2O and > NH3. (v) When nucleophilic and basic sites are same, nucleophilicity parallels basicity. For example, RO- > HO- > R - CO - O-.HO- is a better nucleophile than H2O. NH2(-) is a better nucleophile than NH3. HS(-) is a better nucleophile than H2S. Electronegativity. Nucleophilicity increases as you go to the left along the periodic table. What is difference between Nucleophile and Electrophile? Electrophiles are electron acceptors while nucleophiles are electron donors.Two lists of nucleophiles: H2O CH3CH2OH H3CO- CH3COO- OH- OH- H2N- CH3CH2O- H3COH (CH3)3CO- The first part is to give the strongest nucleophile in group 1. I picked H2N-because its the strongest base. Part two asks for the BEST . You can view more similar questions or ask a new question. Ask a New Question ...

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Strong nucleophiles tend to be strong bases, but the terms are unique. A strong nucleophile is determined based on its reactivity with an electrophile, while a strong base is a molecule that readily accepts a proton from water.